Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response

Weavers, Helen, Evans, Iwan R., Martin, Paul ORCID: https://orcid.org/0000-0002-2665-5086 and Wood, Will 2016. Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response. Cell 165 (7) , pp. 1658-1671. 10.1016/j.cell.2016.04.049

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Abstract

Macrophages are multifunctional cells that perform diverse roles in health and disease. Emerging evidence has suggested that these innate immune cells might also be capable of developing immunological memory, a trait previously associated with the adaptive system alone. While recent studies have focused on the dramatic macrophage reprogramming that follows infection and protects against secondary microbial attack, can macrophages also develop memory in response to other cues? Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential primer for their inflammatory response to tissue damage and infection in vivo. Priming is triggered via calcium-induced JNK signaling, which leads to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell to rapidly respond to subsequent injury or infection. This remarkable plasticity and capacity for memory places macrophages as key therapeutic targets for treatment of inflammatory disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article under the CC BY license.
Publisher:	Elsevier
ISSN:	0092-8674
Date of First Compliant Deposit:	25 October 2018
Date of Acceptance:	13 April 2016
Last Modified:	05 May 2023 22:44
URI:	https://orca.cardiff.ac.uk/id/eprint/102854

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