Clinical correlation between WISP2 and β--Catenin in gastric cancer

Li, Liting, Cui, Yuxin, Ji, Jia F. and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2017. Clinical correlation between WISP2 and β--Catenin in gastric cancer. Anticancer Research 37 (8) , pp. 4469-4473. 10.21873/anticanres.11842

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Abstract

BACKGROUND: Evidence indicates that wingless-type MMTV integration site family, member 1 (WNT1)-inducible signaling pathway protein 2 (WISP2) may play an important role in the development of gastric cancer (GC) by regulating the WNT/β-catenin signaling pathway. In the present study, we investigated whether there is correlation between WISP2 and β-catenin proteins, and their association with clinicopathological features in GC. MATERIALS AND METHODS: Immunohistochemical staining was carried out on 119 paraffin-embedded gastric cancer tissues and 99 adjacent normal gastric tissues collected from patients with GC at the Beijing Cancer Hospital. Data were analyzed by Spearman rank correlation and Chi-square tests. RESULTS: Both WISP2 and β-catenin were more highly expressed in GC tissues compared to adjacent normal tissues. Moreover, Spearman rank correlation analysis showed positive correlation between WISP2 and β-catenin (R=0.2254, p=0.0137). Additionally, their co-expression was seen in a higher proportion of patients with GC at early stage or without metastasis. CONCLUSION: These findings suggest that the expression of WISP2 and β-catenin might be a favorable biomarker for prediction and prognosis in the early stage of GC.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	International Institute of Anticancer Research (IIAR)
ISSN:	0250-7005
Funders:	China Scholarship Council and Cancer Research Wales
Date of Acceptance:	19 June 2017
Last Modified:	02 Nov 2022 11:46
URI:	https://orca.cardiff.ac.uk/id/eprint/103045

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