Intrathecal methotrexate and craniospinal radiotherapy can be an effective treatment of carcinomatous meningitis in patients with breast cancer: case reports

Meissner, Magda and Addeo, Alfredo 2016. Intrathecal methotrexate and craniospinal radiotherapy can be an effective treatment of carcinomatous meningitis in patients with breast cancer: case reports. Case Reports in Oncology 9 (3) , pp. 586-592. 10.1159/000449448

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Abstract

Introduction Carcinomatous meningitis in breast cancer occurs as a complication in up to 5% of all cases. It is a very devastating diagnosis, with a median patient survival of about 3 months. Treatment is very controversial, and different modalities of treatment have been used but none of them show significant benefit for overall survival. Case Reports We report 2 cases of carcinomatous meningitis in breast cancer patients. They received a similar treatment of a combination of intrathecal (IT) methotrexate followed by craniospinal radiotherapy. Both patients survived for many years after treatment and are in complete clinical and radiological remission. Conclusion Meningeal metastasis from breast cancer can be very effectively treated with IT and/or systemic chemotherapy followed by craniospinal radiotherapy. Further studies are needed to determine the effectiveness of this sequential combination of chemotherapy with radiotherapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Uncontrolled Keywords:	Breast cancer; Leptomeningeal carcinoma; Meningeal carcinomatosis; Carcinomatous meningitis; Intrathecal methotrexate; Craniospinal radiotherapy.
Publisher:	Karger
ISSN:	1662-6575
Date of First Compliant Deposit:	29 August 2017
Date of Acceptance:	28 August 2016
Last Modified:	05 May 2023 17:38
URI:	https://orca.cardiff.ac.uk/id/eprint/103240

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