Optimising the glaucoma signal/noise ratio by mapping changes in spatial summation with area-modulated perimetric stimuli

Rountree, Lindsay, Mulholland, Padriag J., Anderson, Roger S., Garway-Heath, David F., Morgan, James E. ORCID: https://orcid.org/0000-0002-8920-1065 and Redmond, Tony ORCID: https://orcid.org/0000-0002-6997-5231 2018. Optimising the glaucoma signal/noise ratio by mapping changes in spatial summation with area-modulated perimetric stimuli. Scientific Reports 8 , 2172. 10.1038/s41598-018-20480-4

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Abstract

Identification of glaucomatous damage and progression by perimetry are limited by measurement and response variability. This study tested the hypothesis that the glaucoma damage signal/noise ratio is greater with stimuli varying in area, either solely, or simultaneously with contrast, than with conventional stimuli varying in contrast only (Goldmann III, GIII). Thirty glaucoma patients and 20 age-similar healthy controls were tested with the Method of Constant Stimuli (MOCS). One stimulus modulated in area (A), one modulated in contrast within Ricco’s area (CR), one modulated in both area and contrast simultaneously (AC), and the reference stimulus was a GIII, modulating in contrast. Stimuli were presented on a common platform with a common scale (energy). A three-stage protocol minimised artefactual MOCS slope bias that can occur due to differences in psychometric function sampling between conditions. Threshold difference from age-matched normal (total deviation), response variability, and signal/noise ratio were compared between stimuli. Total deviation was greater with, and response variability less dependent on defect depth with A, AC, and CR stimuli, compared with GIII. Both A and AC stimuli showed a significantly greater signal/noise ratio than the GIII, indicating that area-modulated stimuli offer benefits over the GIII for identifying early glaucoma and measuring progression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Funders:	College of Optometrists
Date of First Compliant Deposit:	23 January 2018
Date of Acceptance:	18 January 2018
Last Modified:	05 May 2023 16:14
URI:	https://orca.cardiff.ac.uk/id/eprint/108388

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