Spatial summation across the visual field in strabismic and anisometropic amblyopia

Je, Shindy, Ennis, Fergal A ORCID: https://orcid.org/0000-0002-9441-7135, Woodhouse, J. Margaret ORCID: https://orcid.org/0000-0002-7149-5077, Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851 and Redmond, Tony ORCID: https://orcid.org/0000-0002-6997-5231 2018. Spatial summation across the visual field in strabismic and anisometropic amblyopia. Scientific Reports 8 , 3858. 10.1038/s41598-018-21620-6

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Abstract

Ricco’s area (the largest area of visual space in which stimulus area and intensity are inversely proportional at threshold) has previously been hypothesised to be a result of centre/surround antagonism in retinal ganglion cell receptive fields, but recent evidence suggests a sizeable cortical contribution. Here, Ricco’s area was measured in amblyopia, a condition in which retinal receptive fields are normal, to better understand its physiological basis. Spatial summation functions were determined at 12 visual field locations in both eyes of 14 amblyopic adults and 15 normal-sighted controls. Ricco’s area was significantly larger in amblyopic eyes than in fellow non-amblyopic eyes. Compared to the size of Ricco’s area in control eyes, Ricco’s area measured significantly larger in amblyopic eyes. Additionally, Ricco’s area in the fellow, non-amblyopic eye of amblyopic participants measured significantly smaller than in control eyes. Compared to controls, Ricco’s area was larger in amblyopic eyes and smaller in fellow non-amblyopic eyes. Amblyopia type, binocularity, and inter-ocular difference in visual acuity were significantly associated with inter-ocular differences in Ricco’s area in amblyopes. The physiological basis for Ricco’s area is unlikely to be confined to the retina, but more likely representative of spatial summation at multiple sites along the visual pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences Biosciences
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Funders:	College of Optometrists
Date of First Compliant Deposit:	7 February 2018
Date of Acceptance:	7 February 2018
Last Modified:	11 May 2023 21:17
URI:	https://orca.cardiff.ac.uk/id/eprint/108952

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