Superficial layers of the medial entorhinal cortex replay independently of the hippocampus

O'Neill, J. ORCID: https://orcid.org/0000-0003-1886-8476, Boccara, C. N., Stella, F., Schoenenberger, P. and Csicsvari, J. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science 355 (6321) , pp. 184-188. 10.1126/science.aag2787

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Abstract

The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave–ripples, in which synchronous network firing encodes sequences of places. We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave–ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Date of First Compliant Deposit:	12 March 2018
Date of Acceptance:	1 December 2016
Last Modified:	05 Nov 2024 18:07
URI:	https://orca.cardiff.ac.uk/id/eprint/109814

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