Chronic ∆9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats

Wiley, Jenny L. and Burston, James J. 2010. Chronic ∆9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats. Pharmacology Biochemistry and Behavior 94 (4) , pp. 516-523. 10.1016/j.pbb.2009.11.006

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Abstract

Early-onset marijuana use has been associated with short- and long-term deficits in cognitive processing. In human users, self-selection bias prevents determination of the extent to which these effects result only from drug use. This study examined the long-term effects of Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive constituent of marijuana, in a delayed nonmatch-to-position task (DNMP). Male Long–Evans rats were injected daily with 10 mg/kg Δ9-THC during or after adolescence [postnatal days (PN) 21–50 or PN50–79, respectively] or with vehicle. On PN91, training in DNMP was initiated. Successful acquisition and pharmacological challenge began on approximately PN300. Decreases in accuracy were observed at lower doses of Δ9-THC in Δ9-THC-treated rats (versus vehicle-treated rats). Administration of chronic Δ9-THC at a younger age tended to enhance this effect. While anandamide did not decrease accuracy in any group, rats treated with Δ9-THC during adolescence initiated fewer trials at the 30 mg/kg dose of anandamide than did rats in the other two groups. To the extent tested, these differences were pharmacologically selective for cannabinoids, as scopolamine (positive control) decreased accuracy at the same dose in all groups and amphetamine (negative control) did not affect accuracy in any of the groups at doses that did not impair overall responding. These results suggest that repeated administration of a modest dose of Δ9-THC during adolescence (PN21–50) or shortly thereafter (PN50–79) produces a long-term increase in latent sensitivity to cannabinoid-induced impairment of performance in a complex operant task.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0091-3057
Date of Acceptance:	16 November 2009
Last Modified:	11 Jul 2018 12:49
URI:	https://orca.cardiff.ac.uk/id/eprint/112076

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