A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring

Schotten, Christiane, Howard, Joseph L., Jenkins, Robert L., Codina, Anna and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2018. A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring. Tetrahedron 74 (38) , pp. 5503-5509. 10.1016/j.tet.2018.05.070

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Abstract

Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF2H after 105 min.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Elsevier
ISSN:	0040-4020
Date of First Compliant Deposit:	12 June 2018
Date of Acceptance:	23 May 2018
Last Modified:	20 Nov 2024 13:00
URI:	https://orca.cardiff.ac.uk/id/eprint/112196

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