Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens

Guggenheim, Jeremy Andrew, Chen, Paul Yen-Po, Yip, Elaine Yee Ling, Hayet, Hélène, Druel, Vladimir, Wang, Ling, Erichsen, Jonathan Thor, Tumlinson, Alexandre Rex, Považay, Boris, Drexler, Wolfgang and Hocking, Paul M. 2011. Pre-treatment choroidal thickness is not predictive of susceptibility to form-deprivation myopia in chickens. Ophthalmic And Physiological Optics 31 (5) , pp. 516-528. 10.1111/j.1475-1313.2011.00827.x

Full text not available from this repository.


Purpose: Chicks developing experimentally-induced myopia show profound thinning of the choroid. We observed a wide range of choroidal thicknesses in a sample of normal chicks prior to their use in a pedigree-based study of form-deprivation myopia. Hence, we tested whether pre-treatment choroidal thickness predicted susceptibility to myopia. Methods: Retinal, choroidal and scleral thickness were measured using A-scan ultrasonography in normal White Leghorn chicks (n = 891) aged 4 days old, and again (n = 498) after 4 days of monocular form-deprivation at age 8 days of age. Refractive error was assessed by retinoscopy. Relationships between pre-treatment choroidal thickness and other variables were investigated using general linear models and variance components analysis. Results: Untreated 4 day-old male chicks had choroids approximately 10% thinner than females (p < 0.001), but sex explained <2% of the overall variability in choroidal thickness. Axial eye length in these untreated chicks was not significantly associated with choroidal thickness (p = 0.25). Moreover, pre-treatment choroidal thickness was not predictive of susceptibility to form-deprivation myopia (p = 0.89). Heritability analysis suggested that at least 50% of the variation in pre-treatment choroidal thickness was determined by additive genetic effects (p < 0.001). Conclusions: Parental choroidal thickness is the major determinant of choroidal thickness in untreated 4-day old chicks. Despite choroidal thickness potentially being indicative of ongoing emmetropisation to innate refractive errors, in this study it was not predictive of subsequent susceptibility to form-deprivation myopia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: chicken; choroid; myopia; refractive development
Publisher: Blackwell Publishing
ISSN: 0275-5408
Last Modified: 04 Mar 2018 21:19

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item