Testing the importance of the retrosplenial navigation system: lesion size but not strain matters: a reply to Harker and Whishaw

Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 and Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773 2004. Testing the importance of the retrosplenial navigation system: lesion size but not strain matters: a reply to Harker and Whishaw. Neuroscience & Biobehavioral Reviews 28 (5) , pp. 525-531. 10.1016/j.neubiorev.2004.08.003

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Abstract

In their review on the retrosplenial cortex Harker and Whishaw [Neurosci Biobehav Rev, 2004] claim that there is continued disagreement over the importance of this region for navigation. They argue that discrepancies in the published effects of retrosplenial lesions reflect two principal variables, choice of rat strain and choice of spatial task. In this reply, evidence is provided showing that Harker and Whishaw [Neurosci Biobehav Rev, 2004] have created a misleading impression and, in fact, there is a clear consensus that the rat retrosplenial cortex is necessary for navigation. Likewise, there is no dispute that the effects of retrosplenial lesions will differ for different tests of spatial learning. While Harker and Whishaw [Neurosci Biobehav Rev, 2004] also conclude that choice of rat strain has a critical impact on whether a lesion-induced deficit is found, a comprehensive review of the published data shows no systematic strain difference. There is, however, growing evidence that when interpreting the effects of retrosplenial lesions, account should be given of the lesion method and its interaction with lesion size.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0149-7634
Last Modified:	03 Dec 2024 23:05
URI:	https://orca.cardiff.ac.uk/id/eprint/11376

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