Complexity of brain activity and connectivity in functional neuroimaging

Dimitriadis, Stavros ORCID: https://orcid.org/0000-0002-0000-5392 2018. Complexity of brain activity and connectivity in functional neuroimaging. Journal of Neuroscience Research 96 (11) , pp. 1741-1757. 10.1002/jnr.24316

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Abstract

Understanding the complexity of human brain dynamics and brain connectivity across the repertoire of functional neuroimaging and various conditions, is of paramount importance. Novel measures should be designed tailored to the input focusing on multichannel activity and dynamic functional brain connectivity (DFBC). Here, we defined a novel complexity index (CI) from the field of symbolic dynamics that quantifies patterns of different words up to a length from a symbolic sequence. The CI characterizes the complexity of the brain activity. We analysed dynamic functional brain connectivity by adopting the sliding window approach using imaginary part of phase locking value (iPLV) for EEG/ECoG/MEG and wavelet coherence (WC) for fMRI. Both intra and cross-frequency couplings (CFC) namely phase-to-amplitude were estimated using iPLV/WC at every snapshot of the DFBC. Using proper surrogate analysis, we defined the dominant intrinsic coupling mode (DICM) per pair of regions-of-interest (ROI). The spatio-temporal probability distribution of DICM were reported to reveal the most prominent coupling modes per condition and modality. Finally, a novel flexibility index is defined that quantifies the transition of DICM per pair of ROIs between consecutive time-windows. The whole methodology was demonstrated using four neuroimaging datasets (EEG/ECoG/MEG/fMRI). Finally, we succeeded to totally discriminate healthy controls from schizophrenic using FI and dynamic reconfiguration of DICM. Anesthesia independently of the drug caused a global decreased of complexity in all frequency bands with the exception in δ and alters the dynamic reconfiguration of DICM. CI and DICM of MEG/fMRI resting-state recordings in two spatial scales were high reliable.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Publisher:	Wiley
ISSN:	0360-4012
Date of First Compliant Deposit:	31 July 2018
Date of Acceptance:	24 July 2018
Last Modified:	03 Dec 2024 19:30
URI:	https://orca.cardiff.ac.uk/id/eprint/113779

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