GABA levels in left and right sensorimotor cortex correlate across individuals

Puts, Nicolaas A. J., Heba, Stefanie, Harris, Ashley D., Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245, McGonigle, David J. ORCID: https://orcid.org/0000-0001-9595-6352, Tegenthoff, Martin, Schmidt-Wilcke, Tobias and Edden, Richard A. E. 2018. GABA levels in left and right sensorimotor cortex correlate across individuals. Biomedicines 6 (3) , 80. 10.3390/biomedicines6030080

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Abstract

Differences in -aminobutyric acid (GABA) levels measured with Magnetic Resonance Spectroscopy have been shown to correlate with behavioral performance over a number of tasks and cortical regions. These correlations appear to be regionally and functionally specific. In this study, we test the hypothesis that GABA levels will be correlated within individuals for functionally related regions—the left and right sensorimotor cortex. In addition, we investigate whether this is driven by bulk tissue composition. GABA measurements using edited MRS data were acquired from the left and right sensorimotor cortex in 24 participants. T1-weighted MR images were also acquired and segmented to determine the tissue composition of the voxel. GABA level is shown to correlate significantly between the left and right regions (r = 0.64, p < 0.03). Tissue composition is highly correlated between sides, but does not explain significant variance in the bilateral correlation. In conclusion, individual differences in GABA level, which have previously been described as functionally and regionally specific, are correlated between homologous sensorimotor regions. This correlation is not driven by bulk differences in voxel tissue composition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license.
Publisher:	MDPI
ISSN:	2227-9059
Date of First Compliant Deposit:	6 August 2018
Date of Acceptance:	17 July 2018
Last Modified:	04 May 2023 18:06
URI:	https://orca.cardiff.ac.uk/id/eprint/113911

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