Neuroimaging of the fornix: present and future

Denby, C., Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773, Tsivilis, D., Mayes, A., Montaldi, D. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2008. Neuroimaging of the fornix: present and future. Neuroscience Imaging 2 (3) , pp. 135-148.

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Abstract

The fornix is a major white matter tract that is critical for normal memory. Structural magnetic resonance imaging has been employed as a tool for investigating fornix integrity since 1988, when it was first used to link fornix damage to changes in cognition. However, there are still relatively few reports of magnetic resonance imaging (MRI) studies of the fornix, with even fewer studies attempting to provide volumetric estimates of the structure. The fornix is anatomically complex in nature, with its curvature proving a challenge for volumetric analysis. Successful qualitative, and in some cases, quantitative MRI studies examining the integrity of the fornix have been performed in the following patient groups; temporal lobe epilepsy, colloid cyst, schizophrenia, and traumatic brain injury. This review details the current fornix neuroimaging literature, including the anatomy and quantitative methodology used to acquire volume estimates. We also explore new developments in MRI methodology, which will shape the future of fornix neuroimaging.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nova
ISSN:	1556-4010
Last Modified:	07 Nov 2023 11:15
URI:	https://orca.cardiff.ac.uk/id/eprint/11458

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