MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle

Denby, C., Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773, Tsivilis, D., Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308, Mayes, A., Sluming, V., Roberts, N and Montaldi, D 2008. MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle. Neuroscience Imaging 2 (3) , pp. 109-125.

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Abstract

A large cohort of post-surgical colloid cyst patients (n=38) was scanned to provide MR data with which to explore two measures of fornix integrity, overall volume and smallest cross-sectional area. The 3T MRI scans, which provided the first quantitative analysis of fornix volume in this condition, were analysed using a manual segmentation technique. Comparisons were made with 20 healthy age-matched controls. First, inter-rater and intrarater reliability measures were determined for both fornix volume and cross-sectional area from a subset of 20 cases (10 patients, 10 controls). The overall volume measure had acceptable levels of reliability. Subsequent volumetric analyses showed that while the large majority of colloid cyst patients did not suffer complete interruption of the tract, the colloid cyst group had significantly reduced right (368mmsuperscript 3) and left (398mmsuperscript 3) fornix volumes compared to the control volumes (right 507mmsuperscript 3, left 533mmsuperscript 3). Overall, the study revealed that incomplete fornix damage is a common feature in colloid cyst patients. This finding contrasts with the dichotomised descriptions of the fornix (intact or lost) that are more standardly provided after visual inspection of scans. Partial disconnection of the hippocampus is likely to produce long-term memory problems with implications for follow-up monitoring and treatment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Nova
ISSN:	1556-4010
Last Modified:	07 Nov 2023 11:15
URI:	https://orca.cardiff.ac.uk/id/eprint/11459

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