Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint

Barense, Morgan D., Henson, Richard N.A., Lee, Andy C.H. and Graham, Kim Samantha ORCID: https://orcid.org/0000-0002-1512-7667 2010. Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint. Hippocampus 20 (3) , pp. 389-401. 10.1002/hipo.20641

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Abstract

The medial temporal lobe (MTL), a set of heavily interconnected structures including the hippocampus and underlying entorhinal, perirhinal and parahippocampal cortex, is traditionally believed to be part of a unitary system dedicated to declarative memory. Recent studies, however, demonstrated perceptual impairments in amnesic individuals with MTL damage, with hippocampal lesions causing scene discrimination deficits, and perirhinal lesions causing object and face discrimination deficits. The degree of impairment on these tasks was influenced by the need to process complex conjunctions of features: discriminations requiring the integration of multiple visual features caused deficits, whereas discriminations that could be solved on the basis of a single feature did not. Here, we address these issues with functional neuroimaging in healthy participants as they performed a version of the oddity discrimination task used previously in patients. Three different types of stimuli (faces, scenes, novel objects) were presented from either identical or different viewpoints. Consistent with studies in patients, we observed increased perirhinal activity when participants distinguished between faces and objects presented from different, compared to identical, viewpoints. The posterior hippocampus, by contrast, showed an effect of viewpoint for both faces and scenes. These findings provide convergent evidence that the MTL is involved in processes beyond longterm declarative memory and suggest a critical role for these structures in integrating complex features of faces, objects, and scenes into viewinvariant, abstract representations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Systems Immunity Research Institute (SIURI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	hippocampus ; perirhinal cortex ; memory ; perception ; fMRI.
Publisher:	Wiley-Blackwell
ISSN:	1050-9631
Last Modified:	18 Oct 2022 12:53
URI:	https://orca.cardiff.ac.uk/id/eprint/11529

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