Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose

Wolpe, Noham, Zhang, Jiaxiang ORCID: https://orcid.org/0000-0002-4758-0394, Nombela, Cristina, Ingram, James N., Wolpert, Daniel M., CAN, Cam and Rowe, James B. 2018. Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose. Scientific Reports 8 , 15643. 10.1038/s41598-018-33678-3

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Abstract

Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a ‘sensory attenuation’. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger (‘Direct’ condition) or moved a knob that controlled a motor through a linear potentiometer (‘Slider’ condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	9 October 2018
Date of Acceptance:	25 September 2018
Last Modified:	12 May 2023 22:11
URI:	https://orca.cardiff.ac.uk/id/eprint/115690

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