Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze

Xu, Haibing, Baracskay, Peter, O'Neill, Joseph ORCID: https://orcid.org/0000-0003-1886-8476 and Csicsvari, Jozsef 2019. Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze. Neuron 101 (1) , pp. 119-132. 10.1016/j.neuron.2018.11.015

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Abstract

Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these memories influenced CA1 place cell assemblies while reference memories were partially updated. This was contrasted with control tasks requiring only working memory or the update of reference memory. Reference memory update led to the reward-directed place field shifts at newly rewarded arms and to the gradual strengthening of firing in passes between newly rewarded arms but not between those passes that included a familiar-rewarded arm. At the maze center, transient network synchronization periods preferentially replayed trajectories of the next chosen arm in reference memory tasks but the previously visited arm in the working memory task. Hence, reference memory demand was uniquely associated with a gradual, goal novelty-related reorganization of place cell assemblies and with trajectory replay that reflected the animal’s decision of which arm to visit next.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Elsevier (Cell Press)
ISSN:	0896-6273
Date of First Compliant Deposit:	8 November 2018
Date of Acceptance:	5 November 2018
Last Modified:	06 Nov 2024 16:00
URI:	https://orca.cardiff.ac.uk/id/eprint/116567

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