Outcome of cell suspension allografts in a patient with Huntington's disease

Maxan, Alexander, Mason, Sarah, Saint-Pierre, Martine, Smith, Emma, Ho, Aileen, Harrower, Timothy, Watts, Colin, Tai, Yen, Pavese, Nicola, Savage, Julie C., Tremblay, Marie-Ève, Gould, Peter, Rosser, Anne E. ORCID: https://orcid.org/0000-0002-4716-4753, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578, Piccini, Paola, Barker, Roger A. and Cicchetti, Francesca 2018. Outcome of cell suspension allografts in a patient with Huntington's disease. Annals of Neurology 84 (6) , pp. 950-956. 10.1002/ana.25354

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Abstract

For patients with incurable neurodegenerative disorders such as Huntington's (HD) and Parkinson's disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with HD in receipt of cell‐suspension striatal allografts who took part in the NEST‐UK multicenter clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post‐transplantation, but show compromised survival with inflammation and mutant protein being observed within the transplant site.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Publisher:	Wiley
ISSN:	0364-5134
Date of First Compliant Deposit:	12 November 2018
Date of Acceptance:	27 September 2018
Last Modified:	16 Nov 2024 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/116656

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