Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex

Puts, Nicolaas, Edden, Richard A, Muthukumaraswamy, Suresh ORCID: https://orcid.org/0000-0001-7042-3920, Singh, Krish ORCID: https://orcid.org/0000-0002-3094-2475 and McGonigle, David ORCID: https://orcid.org/0000-0001-9595-6352 2019. Induced and evoked properties of vibrotactile adaptation in primary somatosensory cortex. Neural Plasticity 2019 , 5464096. 10.1155/2019/5464096

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Abstract

Prolonged exposure to afferent stimulation (“adaptation”) can cause profound short-term changes in the responsiveness of cortical sensory neurons. While several models have been proposed that link adaptation to single-neuron dynamics, including GABAergic inhibition, the process is currently imperfectly understood at the whole-brain level in humans. Here, we used magnetoencephalography (MEG) to examine the neurophysiological correlates of adaptation within SI in humans. In one condition, a 25 Hz adapting stimulus (5 s) was followed by a 1 s 25 Hz probe (“same”), and in a second condition, the adapting stimulus was followed by a 1 s 180 Hz probe (“different”). We hypothesized that changes in the mu-beta activity band (reflecting GABAergic processing) would be modulated differently between the “same” and “different” probe stimuli. We show that the primary somatosensory (SI) mu-beta response to the “same” probe is significantly reduced () compared to the adapting stimulus, whereas the mu-beta response to the “different” probe is not (). This reduction may reflect sharpening of the spatiotemporal pattern of activity after adaptation. The stimulus onset mu-beta response did not differ between a 25 Hz adapting stimulus and a 180 Hz probe, suggesting that the mu-beta response is independent of stimulus frequency. Furthermore, we show a sustained evoked and induced desynchronization for the duration of the adapting stimulus, consistent with invasive studies. Our findings are important in understanding the neurophysiology underlying short-term and stimulus-induced plasticity in the human brain and shows that the brain response to tactile stimulation is altered after only brief stimulation.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Publisher:	Hindawi Publishing Corporation
ISSN:	2090-5904
Date of First Compliant Deposit:	12 November 2018
Date of Acceptance:	11 November 2018
Last Modified:	07 May 2023 06:34
URI:	https://orca.cardiff.ac.uk/id/eprint/116664

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