Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015

Protty, Majd B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42 (2) , pp. 132-134. 10.1111/jcpt.12481

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Abstract

What is known and objective: Oral anticoagulants (OACs) have been used for decades for the long‐term prevention of arterial and venous thromboembolic disease. These include warfarin and the newer direct‐acting OACs (DOACs). Data on ‘real‐life’ prescribing patterns for DOACs are limited. In this commentary, we report the prescribing patterns for OACs in Wales, as a representative country within the UK. Comment: A retrospective analysis of anonymized OAC prescribing data in Wales from June 2009 to December 2015. Results reveal that the number of OAC prescription items increased from 40·48 to 65·26 per 1000 prescribing unit (PU). Average cost increased from £87·41 to £529·31 per 1000 PU. The share of warfarin prescribing declined from 100% to 68%, with the a rising share for the DOACs, made up of rivaroxaban (19%), apixaban (9%) and dabigatran (3%). What is new and conclusion: Analysis of real‐life data demonstrates that there has been an increase in the overall numbers and costs of OAC prescriptions, with a rising proportion of DOACs to warfarin prescribing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	0269-4727
Date of First Compliant Deposit:	30 November 2018
Date of Acceptance:	25 October 2016
Last Modified:	11 Jan 2019 12:15
URI:	https://orca.cardiff.ac.uk/id/eprint/117238

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