High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks

Kang, Byung Soo, Wang, Li-Ke, Zheng, Yong-Ping, Guggenheim, Jeremy A. ORCID: https://orcid.org/0000-0001-5164-340X, Stell, William K. and Kee, Chea-su 2018. High myopia induced by form deprivation is associated with altered corneal biomechanical properties in chicks. PLoS ONE 13 (11) , e0207189. 10.1371/journal.pone.0207189

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Abstract

The cornea is a soft, transparent, composite organic tissue, which forms the anterior outer coat of the eyeball. Although high myopia is increasing in prevalence worldwide and is known to alter the structure and biomechanical properties of the sclera, remarkably little is known about its impact on the biomechanics of the cornea. We developed and validated a novel optical-coherence-tomography-indentation probe–to measure corneal biomechanical properties in situ, in chicks having experimentally-induced high myopia, while maintaining intraocular pressure at levels covering the physiological range. We found that the cornea of highly myopic chicks was more steeply curved and softer, at all tested intraocular pressures, than that in contralateral, non-myopic eyes, or in age-matched normal, untreated eyes. These results indicate that the biomechanical properties of the cornea are altered in chicks developing experimentally-induced myopia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	Public Library of Science
ISSN:	1932-6203
Funders:	Hong Kong Polytechnic University
Date of First Compliant Deposit:	5 December 2018
Date of Acceptance:	28 October 2018
Last Modified:	05 May 2023 07:39
URI:	https://orca.cardiff.ac.uk/id/eprint/117389

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