Insights into the mechanisms of aquaporin-3 inhibition by gold(III) complexes: the importance of non-coordinative adduct formation

Wenzel, Margot N. ORCID: https://orcid.org/0000-0001-6411-1816, Mósca, Andreia F., Graziani, Valentina, Aikman, Brech, Thomas, Sophie R., De Almeida, Andreia ORCID: https://orcid.org/0000-0002-6889-1503, Platts, James A. ORCID: https://orcid.org/0000-0002-1008-6595, Re, Nazzareno, Coletti, Cecilia, Marrone, Alessandro, Soveral, Graça and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2019. Insights into the mechanisms of aquaporin-3 inhibition by gold(III) complexes: the importance of non-coordinative adduct formation. Inorganic Chemistry 58 (3) , -. 10.1021/acs.inorgchem.8b03233

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Abstract

A series of six new Au(III) coordination compounds with phenanthroline ligands have been synthesized and studied for the inhibition of the water and glycerol channel aquaporin-3 (AQP3). From a combination of different experimental and computational approaches, further insights into the mechanisms of AQP3 inhibition by gold compounds at a molecular level have been gained. The results evidence the importance of noncoordinative adduct formation, prior to “covalent” protein binding, to achieve selective AQP3 inhibition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Advanced Research Computing @ Cardiff (ARCCA)
Publisher:	American Chemical Society
ISSN:	0020-1669
Date of First Compliant Deposit:	16 January 2019
Date of Acceptance:	3 January 2019
Last Modified:	06 Nov 2024 13:00
URI:	https://orca.cardiff.ac.uk/id/eprint/118439

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