Morpholin-2-one derivatives via intramolecular acid-catalyzed hydroamination

Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 and Knight, David 2019. Morpholin-2-one derivatives via intramolecular acid-catalyzed hydroamination. SYNTHESIS 51 (07) , pp. 1643-1648. 10.1055/s-0037-1610674

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Abstract

Substituted morpholin-2-one derivatives were readily obtained in two steps starting from commercially available N-protected amino acids. In a metal-free and practical method, a catalytic amount of trifluoromethanesulfonic acid was sufficient to generate morpholinones under mild reaction conditions in an intramolecular hydroamination reaction in good to excellent yields.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Thieme Publishing / Georg Thieme Verlag
ISSN:	0039-7881
Date of First Compliant Deposit:	16 January 2019
Date of Acceptance:	6 November 2018
Last Modified:	24 Nov 2024 07:00
URI:	https://orca.cardiff.ac.uk/id/eprint/118441

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