Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes

Morgan, Sarah E., Seidlitz, Jakob, Whitaker, Kirstie J., Romero-Garcia, Rafael, Clifton, Nicolas E. ORCID: https://orcid.org/0000-0003-2597-5253, Van Amelsvoort, Therese, Marcelis, Machteld, Van Os, Jim, Donohoe, Gary, Mothersill, David, Corving, Aiden, Pocklington, Andrew ORCID: https://orcid.org/0000-0002-2137-0452, Raznahan, Armin, Vértesa, Petra E. and Bullmore, Edward T. 2019. Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes. Proceedings of the National Academy of Sciences 116 (19) , pp. 9604-9609. 10.1073/pnas.1820754116

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Abstract

Despite significant research, the biological mechanisms underlying schizophrenia are still unclear. We shed light on structural brain differences in psychosis using an approach called morphometric similarity mapping, which quantifies the structural similarity between brain regions. Morphometric similarity was globally reduced in psychosis patients in three independent datasets, implying that patients’ brain regions were more differentiated from each other and less interconnected. Similarity was especially decreased in frontal and temporal regions. This anatomical pattern was correlated with expression of genes enriched for nervous system development and synaptic signaling and genes previously associated with schizophrenia and antipsychotic treatments. Therefore, we begin to see how combining genomics and imaging can give a more integrative understanding of schizophrenia, which might inform future treatments.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). Original title: Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of genes
Publisher:	National Academy of Sciences
ISSN:	0027-8424
Date of First Compliant Deposit:	20 June 2019
Date of Acceptance:	21 March 2019
Last Modified:	05 May 2023 21:56
URI:	https://orca.cardiff.ac.uk/id/eprint/121229

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