Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents

Wilson, Thomas C., McSweeney, Greg, Preshlock, Sean, Verhoog, Stefan, Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611, Cailly, Thomas and V{e 2016. Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents. Chemical Communications 52 (90) , 13277--13280. 10.1039/c6cc07417k

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Abstract

A general method for the copper mediated nucleophilic 123I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [123I]DPA-713, [123I]IMPY, [123I]MIBG and [123I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date of Acceptance:	12 October 2016
Last Modified:	04 Nov 2022 12:12
URI:	https://orca.cardiff.ac.uk/id/eprint/122232

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