Correlation of TERT and stem cell markers in the context of human breast cancer

Wazir, Umar, Orakzai, Mona M. A. W., Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 and Mokbel, Kefah 2019. Correlation of TERT and stem cell markers in the context of human breast cancer. Cancer Genomics and Proteomics 16 (2) , pp. 121-127. 10.21873/cgp.20117

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Abstract

Background: Telomerase reverse transcriptase (TERT) has a well-known role in carcinogenesis due to its functions in inducing cell immortality and preventing senescence. In this study, the relationships between TERT and a panel of known stem cell markers was examined in order to direct future enquiries into the role of ‘stem-ness’ in human breast cancer. Materials and Methods: Breast cancer tissues (n=124) and adjacent normal tissues (n=30) underwent reverse transcription and quantitative polymerase chain reaction. Transcript levels were analyzed for the correlation with that of TERT. Results: A significant direct correlation was found in cancerous tissue between TERT and BMI1 proto-oncogene polycomb ring finger 4 (BMI1; n=88, p<0.001), nestin (NES; n=88, p<0.001), POU domain, class 5, transcription factor 1 (POU5F1; n=88, p<0.001), aldehyde dehydrogenase 1 family member A2 (ALDH1A2; n=87, p=0.0298), cyclin-dependent kinase inhibitor 1A (CDKN1A; n=88, p<0.001), integrin subunit beta 1 (ITGNB1; n=88, p<0.001), integrin subunit alpha 6 (ITGA6; n=88, p<0.001), cluster of differentiation antigen 24 (CD24; n=88, p=0.0114), MET proto-oncogene (MET; n=78, p<0.001) and noggin (NOG; n=88, p<0.001). Conclusion: The evidence presented in this article of possible interactions between TERT and a discrete subset of known stem cell markers would significantly contribute to further enquiries regarding clonal dynamics in the context of human breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	International Institute of Anticancer Research (IIAR)
ISSN:	1109-6535
Date of First Compliant Deposit:	6 June 2019
Date of Acceptance:	26 February 2019
Last Modified:	06 May 2023 03:16
URI:	https://orca.cardiff.ac.uk/id/eprint/123245

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