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Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies

Frew, J.W., Navrazhina, K., Byrd, A.S., Garg, A., Ingram, J.R., Kirby, J.S., Lowes, M.A., Naik, H., Piguet, V. and Prens, E.P. 2019. Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies. British Journal of Dermatology 181 (6) 10.1111/bjd.18309

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Abstract

Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory skin condition for which the pathogenesis is not completely elucidated1. With the increase in HS‐related research comes the need to enhance reproducibility, quality and accuracy of scientific methods. Unlike other inflammatory dermatoses such as psoriasis or atopic dermatitis, HS lesions are morphologically diverse and include nodules, abscesses, tunnels and fibrosis in various permutations and combinations admixed in the same anatomical region1. This makes general definitions as ‘lesional’ and ‘non‐lesional’ insufficient for HS‐related investigations. A definition for non‐lesional skin is lacking.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 0007-0963
Date of First Compliant Deposit: 16 July 2019
Date of Acceptance: 7 July 2019
Last Modified: 07 Oct 2021 01:51
URI: http://orca.cardiff.ac.uk/id/eprint/124259

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