Mammillothalamic disconnection alters hippocampocortical oscillatory activity and microstructure: Implications for diencephalic amnesia

Dillingham, Christopher M., Milczarek, Michal M., Perry, James C., Frost, Bethany E., Parker, Greg D., Assaf, Yaniv, Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851, O'Mara, Shane M. and Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 2019. Mammillothalamic disconnection alters hippocampocortical oscillatory activity and microstructure: Implications for diencephalic amnesia. Journal of Neuroscience 39 (34) , pp. 6696-6713. 10.1523/JNEUROSCI.0827-19.2019

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Abstract

Diencephalic amnesia can be as debilitating as the more commonly known temporal lobe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elusive. Across four cohorts of male rats, we used discrete lesions of the mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these lesions on multiple measures of activity and plasticity within the hippocampus and retrosplenial cortex. Lesions of the mammillothalamic tract had widespread indirect effects on hippocampo-cortical oscillatory activity within both theta and gamma bands. Both within-region oscillatory activity and cross-regional synchrony were altered. The network changes were state-dependent, displaying different profiles during locomotion and paradoxical sleep. Consistent with the associations between oscillatory activity and plasticity, complementary analyses using several convergent approaches revealed microstructural changes, which appeared to reflect a suppression of learning-induced plasticity in lesioned animals. Together, these combined findings suggest a mechanism by which damage to the medial diencephalon can impact upon learning and memory processes, highlighting an important role for the mammillary bodies in the co-ordination of hippocampo-cortical activity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Psychology
Additional Information:	This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher:	Society for Neuroscience
ISSN:	1529-2401
Funders:	Wellcome Trust
Date of First Compliant Deposit:	5 August 2019
Date of Acceptance:	10 June 2019
Last Modified:	07 Nov 2023 11:16
URI:	https://orca.cardiff.ac.uk/id/eprint/124704

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