Dependence on Dectin-1 varies with multiple candida species

Thompson, Aiysha, Griffiths, James S., Walker, Louise, Matos da Fonseca, Diogo, Lee, Keunsook K., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Gow, Neil A. R. and Orr, Selinda J. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10 , 1800. 10.3389/fmicb.2019.01800

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (4MB) | Preview

Abstract

Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Frontiers Media
ISSN:	1664-302X
Funders:	Wellcome Trust
Date of First Compliant Deposit:	18 September 2019
Date of Acceptance:	22 July 2019
Last Modified:	24 May 2024 18:20
URI:	https://orca.cardiff.ac.uk/id/eprint/125516

Citation Data

Cited 21 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item