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Regioselective control of electrophilic aromatic substitution reactions

Smith, Keith and El-Hiti, Gamal A. 2004. Regioselective control of electrophilic aromatic substitution reactions. Current Organic Synthesis 1 (3) , pp. 253-274. 10.2174/1570179043366747

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para-Regioselective electrophilic aromatic substitution reactions, for example nitration, alkylation, acylation, sulfonylation and halogenation, can be achieved by carrying out reactions over solid catalysts such as zeolites, under modest conditions via shape-selectivity. By contrast, organolithium reagents can play an important role when ortho-products are desirable. ortho-Lithiation has been applied for the synthesis of more complex substituted heterocycles that are difficult to prepare by other means.

Item Type: Article
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: regioisomers; zeolites; electrophilic aromatic substitution reactions; directed lithiation; shape selectivity; heterocycles
Publisher: Bentham Science
ISSN: 1570-1794
Last Modified: 04 Jun 2017 02:51

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