Advances in the understanding of cellular pathogenesis associated with Autism Spectrum Disorder

Savory, Katrina and Syed, Yasir Ahmed ORCID: https://orcid.org/0000-0001-9495-307X 2020. Advances in the understanding of cellular pathogenesis associated with Autism Spectrum Disorder. Journal for ReAttach Therapy and Developmental Diversities 2 (2) , pp. 96-118.

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Abstract

Autism Spectrum Disorders (ASD) are a group of heterogeneous neurodevelopmental disorders with an estimated worldwide prevalence of 1-2%. Although it is highly heritable, the contribution of environmental factors and risk associated genes on the aberrant brain development is not well understood.In this review, we summarise some of the key risk factors and explore ASD associated cellular pathology from the perspective of the four predominant cells in the brain; neurons, oligodendrocytes, microglia and astrocytes. Further, we discuss the contributions of the associated cellular pathology to the three common hypotheses of ASD.We highlight the major neuro-pathologies underlying ASD, however more research is needed to ensure appropriate and efficient therapies can be directed towards ASD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
ISSN:	2589-7799
Date of First Compliant Deposit:	25 November 2019
Date of Acceptance:	21 November 2019
Last Modified:	03 May 2023 00:33
URI:	https://orca.cardiff.ac.uk/id/eprint/127118

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