Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis

Stock, M., Distler, A., Distler, J., Beyer, C., Ruiz-Heiland, G., Ipseiz, N. ORCID: https://orcid.org/0000-0001-5008-8889, Seeling, M., Kroenke, G., Nimmerjahn, F. and Schett, G. 2015. Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis. Osteoarthritis and Cartilage 23 (7) , pp. 1221-1225. 10.1016/j.joca.2015.02.019

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Abstract

Fc-gamma receptors (FcγRs) have been shown to play a crucial role in cartilage degradation during experimental arthritis. Although most of their effect on cartilage degradation has been attributed to their potential to promote inflammation in the presence of immunoglobulins, activating FcγRs promote cartilage degeneration in antigen-induced arthritis (AIA) independently of the level of inflammation. This prompted us to investigate, whether FcγRs may also play a role in osteoarthritis (OA)-related cartilage degradation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	1063-4584
Date of Acceptance:	13 February 2015
Last Modified:	10 Jun 2023 01:45
URI:	https://orca.cardiff.ac.uk/id/eprint/127544

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