Stable encoding of visual cues in the mouse retrosplenial cortex

Powell, Anna ORCID: https://orcid.org/0000-0003-2070-856X, Connelly, William M., Vasalauskaite, Asta, Nelson, Andrew J. D. ORCID: https://orcid.org/0000-0002-5171-413X, Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773, Aggleton, John P. ORCID: https://orcid.org/0000-0002-5573-1308, Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851 and Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832 2020. Stable encoding of visual cues in the mouse retrosplenial cortex. Cerebral Cortex 30 (8) , pp. 4424-4437. 10.1093/cercor/bhaa030

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Abstract

The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation and memory. While RSC is reciprocally connected with the sensory cortex, the form in which sensory information is represented in the RSC and how it interacts with motor feedback is unclear and likely to be critical to computations involved in navigation such as path integration. Here, we used 2-photon cellular imaging of neural activity of putative excitatory (CaMKII expressing) and inhibitory (parvalbumin expressing) neurons to measure visual and locomotion evoked activity in RSC and compare it to primary visual cortex (V1). We observed stimulus position and orientation tuning, and a retinotopic organization. Locomotion modulation of activity of single neurons, both in darkness and light, was more pronounced in RSC than V1, and while locomotion modulation was strongest in RSC parvalbumin-positive neurons, visual-locomotion integration was found to be more supralinear in CaMKII neurons. Longitudinal measurements showed that response properties were stably maintained over many weeks. These data provide evidence for stable representations of visual cues in RSC that are spatially selective. These may provide sensory data to contribute to the formation of memories of spatial information.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Biosciences Neuroscience and Mental Health Research Institute (NMHRI) Medicine
Additional Information:	This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher:	Oxford University Press
ISSN:	1047-3211
Funders:	Wellcome Trust
Date of First Compliant Deposit:	29 January 2020
Date of Acceptance:	24 December 2019
Last Modified:	07 Nov 2023 11:16
URI:	https://orca.cardiff.ac.uk/id/eprint/129110

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