Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies

Murray, Alexander T., Challinor, Jonathan D., Gulácsy, Christina E., Lujan, Cristina, Hatcher, Lauren E. ORCID: https://orcid.org/0000-0002-1549-9727, Pudney, Christopher R., Raithby, Paul R., John, Matthew P. and Carbery, David R. 2016. Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies. Organic and Biomolecular Chemistry 14 (15) , pp. 3787-3792. 10.1039/C6OB00361C

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Abstract

The formation and chemistry of flavin–indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic studies. Single crystals of sufficient quality of a flavin–indole CT complex, suitable for X-ray diffraction, have been grown, allowing solid-state structural analysis. When CT complex formation is conducted in d4-methanol, an efficient and synthetically useful C-3 indole deuteration is observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1477-0520
Date of Acceptance:	15 March 2016
Last Modified:	07 Nov 2022 09:52
URI:	https://orca.cardiff.ac.uk/id/eprint/130490

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