Cortical and subcortical functional specificity associated with response inhibition

Maizey, Leah, Evans, C. John ORCID: https://orcid.org/0000-0002-6619-4245, Muhlert, Nils, Vergruggen, Frederick, Chambers, Christopher D. ORCID: https://orcid.org/0000-0001-6058-4114 and Allen, Christopher P. G. 2020. Cortical and subcortical functional specificity associated with response inhibition. NeuroImage 220 , 117110. 10.1016/j.neuroimage.2020.117110

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Abstract

The existence of specific neuronal systems dedicated for response inhibition, as opposed to more general action updating, is controversial. This pre-registered study employed a task involving both inhibitory and non-inhibitory action updating in combination with functional magnetic resonance imaging to test the specificity of responses under different updating conditions, including the cessation of actions. Cortical regions of activity were found to be common to multiple forms of action updating. However, functional specificity during response inhibition was observed in the anterior right Inferior Frontal Gyrus. In addition, we developed an exploratory contrast method which suggested this specificity continued downstream to subcortical loci, with right hemisphere activity largely supporting response inhibition, and left hemisphere activity associated with right hand response execution. The pattern of activations supports putative models of subcortical pathways and extends them through the demonstration of lateralisation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	1053-8119
Funders:	Wellcome Trust, BBSRC
Date of First Compliant Deposit:	30 June 2020
Date of Acceptance:	27 June 2020
Last Modified:	29 Oct 2024 02:05
URI:	https://orca.cardiff.ac.uk/id/eprint/132894

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