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Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer

Angelopoulos, Nicos, Stebbing, Justin, Xu, Yichen, Giamas, Georgios and Zhang, Hua 2016. Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer. Data in Brief 7 , pp. 740-746. 10.1016/j.dib.2016.03.024

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Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier: Creative Commons Attribution / Elsevier
ISSN: 2352-3409
Date of First Compliant Deposit: 6 August 2020
Date of Acceptance: 4 March 2016
Last Modified: 06 Aug 2020 12:00

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