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Polymer colloids as drug delivery systems for the treatment of arthritis

Saeedi, Tahani, Alotaibi, Hadil Faris and Prokopovich, Polina 2020. Polymer colloids as drug delivery systems for the treatment of arthritis. Advances in Colloid and Interface Science 285 , 102273. 10.1016/j.cis.2020.102273

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Abstract

The most common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA) which are themain causes of disability and pain among older people. Current treatment of arthritis mainly consists of oral and intra-articular medications. Despite the efficacy of the intraarticular injections over the oral treatment, it is still limited by the rapid clearance of the injected drug. Therefore, a rational design of drug delivery systems (DDSs) able to delivery drugs in controlled manner and for required period of time to the arthritis joint is a key in developing safe and effective formulations for OA and RA. In this paper various colloidal systems like nanoparticles, liposomes, cationic carriers, hydrogels, and emulsion-based carriers were presented and discussed in light of their use and efficacy as delivery systems to transport therapeutics for arthritis treatment. Factors influencing the delivery efficacy such as size, charge, structure, drug uptake, retention and its release profile alongside with cytocompatibility and safety were addressed. Moreover, the advantages and disadvantages of the different colloidal systems were emphasised.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Elsevier
ISSN: 0001-8686
Date of First Compliant Deposit: 27 October 2020
Date of Acceptance: 18 September 2020
Last Modified: 08 Oct 2021 02:50
URI: http://orca.cardiff.ac.uk/id/eprint/135963

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