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Expedient organocatalytic Aza-Morita–Baylis–Hillman reaction through ball-milling

Williams, Matthew T. J., Morrill, Louis C. and Browne, Duncan L. 2020. Expedient organocatalytic Aza-Morita–Baylis–Hillman reaction through ball-milling. ACS Sustainable Chemistry and Engineering 8 (48) , pp. 17876-17881. 10.1021/acssuschemeng.0c07320

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Abstract

A ball-milling enabled tertiary amine catalyzed aza-Morita–Baylis–Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 2168-0485
Funders: EPSRC
Date of First Compliant Deposit: 3 December 2020
Date of Acceptance: 9 November 2020
Last Modified: 14 Jan 2021 09:33
URI: http://orca.cardiff.ac.uk/id/eprint/136753

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