The soluble sperm factor that activates the egg: PLCzeta and beyond

Swann, Karl ORCID: https://orcid.org/0000-0002-4355-1449 2020. The soluble sperm factor that activates the egg: PLCzeta and beyond. Reproduction 160 (1) 10.1530/REP-20-0079

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Abstract

PLCzeta(ζ) initiates Ca2+ oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca2+ release. Here, I propose a hypothesis for how this second sperm factor might cause Ca2+ oscillations in mouse eggs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	BioScientifica
ISSN:	1470-1626
Date of First Compliant Deposit:	6 January 2021
Date of Acceptance:	30 April 2020
Last Modified:	16 Nov 2024 00:45
URI:	https://orca.cardiff.ac.uk/id/eprint/137378

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