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Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx

Cui, Xinjiang, Yuan, Hangkong, Li, Jerry-Peng, De Campo, Floryan, Pera-Titus, Marc, Deng, Youquan and Shi, Feng 2015. Novel route for the synthesis of 8-oxa-3-azabicyclo[3.2.1]octane: One-pot aminocyclization of 2,5-tetrahydrofurandimethanol catalyzed by Pt/NiCuAlOx. Catalysis Communications 58 , pp. 195-199. 10.1016/j.catcom.2014.09.027

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Abstract

2,5-Tetrahydrofurandimethanol (THFDM) was selectively transformed into 8-oxa-3-azabicyclo[3.2.1] octane (OABCO), a valuable building block for the synthesis of bioactive molecules, via one-pot aminocyclization with ammonia catalyzed by Pt/NiCuAlOx. Under optimized conditions (200 °C, 6–16 h, 0.5 MPa hydrogen, 0.4 MPa ammonia), the OABCO yield reached 58% with 100% THFDM conversion.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: Elsevier
ISSN: 1566-7367
Date of Acceptance: 16 September 2014
Last Modified: 11 Jan 2021 16:15
URI: http://orca.cardiff.ac.uk/id/eprint/137432

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