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Synthesis, characterization and DNA-binding properties of La(III) complex of chrysin

Zeng, Yi-Bo, Yang, Nan, Liu, Wei-Sheng and Tang, Ning 2003. Synthesis, characterization and DNA-binding properties of La(III) complex of chrysin. Journal of Inorganic Biochemistry 97 (3) , pp. 258-264. 10.1016/S0162-0134(03)00313-1

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Abstract

A novel La(III) complex of chrysin (5,7-dihydroxyflavone) was synthesized and characterized by UV, IR, 1H NMR, thermogravimetry/differential thermal analysis (TG/DTA) and elementary analyses. The interactions of the La(III) complex and chrysin with calf thymus DNA were investigated by spectrophotometric methods and viscosity measurements. The intrinsic binding constants of La(III) complex and chrysin are 1.29×106 and 5.44×105 M−1, respectively. Experimental results indicated that La(III) complex and chrysin can both bind to DNA by intercalation modes, but the binding affinity of La(III) complex is much higher than that of chrysin. Comparative antitumor activities of La(III) complex and chrysin were tested by MTT and SRB methods. The results show that at the concentration of 10 μM for chrysin and La(III) complex, the inhibitory ratios of La(III) complex against the tested tumor cells were higher than those of chrysin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: Elsevier
ISSN: 0162-0134
Date of Acceptance: 11 August 2003
Last Modified: 03 Feb 2021 15:16
URI: http://orca.cardiff.ac.uk/id/eprint/138158

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