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Optimization of radionuclidic purity and yield of cyclotron based nuclear reactions in the production of metallic pet radioisotopes.

Dabkowski, Adam 2020. Optimization of radionuclidic purity and yield of cyclotron based nuclear reactions in the production of metallic pet radioisotopes. PhD Thesis, Cardiff University.
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Cyclotron productions for the radiometals of 89Zr, 48V, 99mTc and 68Ga were investigated to find optimal conditions according to results of FLUKA code Monte Carlo modelling irradiation processes, nuclear reactions and target design. Experimental validation (making cyclotron productions for expected high product yield and low impurities’ levels followed by activity measurements, spectra acquisitions and chemical separation procedures) for strategies developed by computer models’ analysis were carried out in the IBA CYCLONE® 18/9 cyclotron, permitting a comparison of the predicted and actual yields of produced radiometals and isotopic by-products (impurities) mostly for 89Zr and 48V. Once the in-silica model was validated experimentally, then optimal method of the radiometal production in the cyclotron was developed. Results achieved with 89Zr and 48V, enabled expansion of the FLUKA model to other radiometal isotopes like 99mTc and 68Ga. Optimisation of cyclotron production for those radiometals may help to keep the high rate of innovation and development in domains of theransostics, nuclear medicine and positron emission tomography (PET). Providing a wide range of isotopes with a variety of parameters like half-lives will help labelling new agents more specific for the tasks of molecular imaging and therapy. Optimized cyclotron production of 99mTc may solve problems with resources of the 99Mo for generators of 99mTc eluents used in nuclear medicine. Aging nuclear reactor fleet and planned shutdowns of key reactors can cause serious problems especially in Canada and United States. In this project a tool for optimization of the solid target production of radiometals was developed, that can be easily modified for the most common and commercially available types of the solid target stations (STS). One such solid target system is the COSTIS STS, also known as the Nitra Solid Compact, designed by Elex Commerce for IBA cyclotrons.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Date of First Compliant Deposit: 5 February 2021
Last Modified: 05 Feb 2021 10:04

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