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5-HT/GABA interaction in neurodevelopment and plasticity

Deidda, Gabriele, Pierucci, Massimo, Crunelli, Vincenzo and Di Giovanni, Giuseppe 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. Progress in Brain Research 259 , pp. 287-317. 10.1016/bs.pbr.2021.01.009

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Abstract

The adult brain is the result of a multistages complex neurodevelopmental process involving genetic, molecular and microenvironmental factors as well as diverse patterns of electrical activity. In the postnatal life, immature neuronal circuits undergo an experience-dependent maturation during critical periods of plasticity, but the brain still retains plasticity during adult life. In all these stages, the neurotransmitter GABA plays a pivotal role. In this chapter, we will describe the interaction of 5-HT with GABA in regulating neurodevelopment and plasticity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: ELSEVIER SCIENCE BV
ISSN: 0079-6123
Last Modified: 09 Feb 2021 15:30
URI: http://orca.cardiff.ac.uk/id/eprint/138337

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