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Photosensitized intermolecular carboimination of alkenes through the persistent radical effect

Patra, Tuhin, Bellotti, Peter, Strieth-Kalthoff, Felix and Glorius, Frank 2020. Photosensitized intermolecular carboimination of alkenes through the persistent radical effect. Angewandte Chemie International Edition 59 (8) , pp. 3172-3177. 10.1002/anie.201912907

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Abstract

An intermolecular, two‐component vicinal carboimination of alkenes has been accomplished by energy transfer catalysis. Oxime esters of alkyl carboxylic acids were used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, addition of the alkyl radical to an alkene generates a transient radical for selective radical–radical cross‐coupling with the persistent iminyl radical. Furthermore, this process provides direct access to aliphatic primary amines and α‐amino acids by simple hydrolysis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Additional Information: This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License
Publisher: Wiley
ISSN: 1433-7851
Date of First Compliant Deposit: 10 February 2021
Date of Acceptance: 3 December 2019
Last Modified: 15 Feb 2021 11:06
URI: http://orca.cardiff.ac.uk/id/eprint/138437

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