The effects of midazolam on the acquisition and expression of fructose- and maltodextrin-based flavour preferences

Dwyer, Dominic M. ORCID: https://orcid.org/0000-0001-8069-5508 2009. The effects of midazolam on the acquisition and expression of fructose- and maltodextrin-based flavour preferences. Pharmacology, Biochemistry and Behavior 91 (4) , pp. 503-510. 10.1016/j.pbb.2008.09.001

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Abstract

The effects of the benzodiazepine agonist midazolam on the acquisition and expression of flavour preferences were investigated. Rats (Experiment 1) were given one-bottle training with one flavoured solution (CS+) mixed with either fructose or maltodextrin and another solution (CS−) presented alone. Animals receiving 1 mg/kg midazolam during training consumed more CS− than did animals receiving vehicle injections although there was no drug effect on CS+ consumption. In two-bottle tests the CS+ was preferred to the CS− with the preference being larger in fructose trained animals. Midazolam (0.3–3 mg/kg) increased total intake but not CS+ preference. Training under midazolam reduced the CS+ preference when fructose, but not maltodextrin, was the reinforcer. In Experiment 2 training consumption was restricted to 10 ml/session. This removed the difference in CS+ preference between reinforcer types but otherwise the results were as in Experiment 1. The midazolam induced attenuation of fructose-based preferences might reflect an increase in CS− palatability during training which would reduce the difference between the reinforced and non-reinforced solutions. As maltodextrin supports preferences due to post-ingestive effects manipulation of palatability should be ineffective. Midazolam does not influence the expression of conditioned flavour preferences despite prior evidence that benzodiazepine agonists enhance palatability.

Item Type:	Article
Status:	Published
Schools:	Psychology
Subjects:	Q Science > QP Physiology
Uncontrolled Keywords:	Flavour–flavour learning; Flavour–nutrient learning; Sweet taste; Post-ingestive effects
Publisher:	Elsevier
ISSN:	0091-3057
Last Modified:	18 Oct 2022 13:26
URI:	https://orca.cardiff.ac.uk/id/eprint/13861

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