Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis.

Rovaris, Marco, Iannucci, Giuseppe, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Sormani, Maria Pia, De Stefano, Nicola, Gerevini, Simonetta, Comi, Giancarlo and Filippi, Massimo 2003. Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis. Radiology 227 (3) , pp. 731-738. 10.1148/radiol.2273020721

Full text not available from this repository.

Abstract

PURPOSE: To investigate the influence of aging on conventional magnetic resonance (MR) imaging-, magnetization transfer MR imaging-, and diffusion-tensor MR imaging-derived measurements. MATERIALS AND METHODS: Dual-echo T1-weighted magnetization transfer and diffusion-tensor MR images of the brain were obtained in 89 healthy subjects. Normalized brain parenchymal volume (NBV) was measured by using a fully automated technique. Magnetization transfer ratio (MTR), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) histograms were created for the whole brain (MTR values) or for a large representative portion of it (ADC and FA values). Bivariate correlations were assessed by using the Spearman rank correlation coefficient. A stepwise selection procedure was used to identify the combination of variables that were most influenced by subject age in a multivariate regression model. RESULTS: Significant correlations were found between subject age and the following variables: number of hyperintense areas in the brain at T2-weighted MR imaging (r = 0.63, P <.001), NBV (r = -0.79, P <.001), mean ADC (r = 0.34, P =.001), ADC peak height (r = -0.34, P =.001), and FA peak height (r = -0.57, P <.001). NBV correlated significantly with number of hyperintense areas (P <.001), MTR peak height (P <.001), mean ADC (P =.001), ADC peak height (P =.001), and FA peak height (P <.001). The final multivariable regression model included NBV and number of hyperintense areas at T2-weighted MR imaging as independent predictors of subject age. CONCLUSION: In addition to the extent of T2-weighted MR imaging hyperintense areas and the measurement of NBV, diffusion-tensor MR imaging provides additional in vivo information about microstructural age-related brain tissue changes.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Radiological Society of North America (RSNA)
ISSN:	0033-8419
Last Modified:	09 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/139468

Citation Data

Cited 120 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item