Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study

Sepulcre, Jorge, Sastre-Garriga, Jaume and Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 2006. Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. JAMA Neurology 63 (8) , pp. 1175-1180. 10.1001/archneur.63.8.1175

Full text not available from this repository.

Abstract

<h4>Background</h4>Gray matter (GM) atrophy has been reported in multiple sclerosis (MS). However, little is known about its regional distribution.<h4>Objective</h4>To investigate the regional distribution of GM atrophy in clinically early primary progressive MS (PPMS).<h4>Design and patients</h4>Thirty-one patients with PPMS within 5 years of symptom onset (mean age, 43.2 years; median Expanded Disability Status Scale score, 4.5) and 15 healthy control subjects (mean age, 43.7 years) were studied. All subjects underwent a 3-dimensional inversion-recovery fast spoiled gradient-recalled echo sequence that was repeated after 1 year in patients only. Magnetic resonance images underwent an optimized voxel-based morphometric analysis that segments magnetic resonance data volumes in a normalized space and quantifies tissue atrophy on a voxel-by-voxel basis. A lesion mask was created for each patient and used in normalization and segmentation steps to minimize bias from lesions. A multisubject design was used in the cross-sectional study to compare patients with PPMS and controls. A 1-way analysis of variance (within-subjects) design was used in the longitudinal study.<h4>Results</h4>At baseline, patients with PPMS displayed bilateral thalamic atrophy compared with controls. In addition, a significant association between lesion load and decreased GM volume was found for the thalami. Loss of GM in the putamen, caudate, thalami, and cortical and infratentorial areas was observed in patients after 1 year of follow-up.<h4>Conclusions</h4>Atrophy is most obvious in deep GM in clinically early PPMS. This may reflect increased sensitivity of these regions to neurodegeneration. Cortical and infratentorial atrophy developed as the disease evolved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: American Medical Association (AMA)
ISSN: 2168-6149
Date of Acceptance: 10 March 2006
Last Modified: 09 Nov 2022 10:26
URI: https://orca.cardiff.ac.uk/id/eprint/139481

Citation Data

Cited 139 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item