Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matter

Raz, Eytan, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Sbardella, Emilia, Totaro, Porzia, Pozzilli, Carlo, Bozzali, Marco and Pantano, Patrizia 2009. Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matter. Radiology 254 (1) 10.1148/radiol.2541090817

Full text not available from this repository.

Abstract

Purpose To quantify white matter (WM) and gray matter (GM) damage in patients who presented with clinically isolated syndrome (CIS), which is suggestive of multiple sclerosis (MS), by combining volume-based morphometry (VBM) and tract-based spatial statistics (TBSS). Materials and Methods This prospective HIPAA-compliant study was approved by the institutional review board. Written informed consent was obtained from all participants. In this study, 34 consecutive patients (21 women, 13 men; mean age, 31.7 years ± 7.7 [standard deviation]) who presented with CIS were recruited. The magnetic resonance (MR) examination included dual-echo fast spin-echo, three-dimensional T1, and diffusion-tensor imaging. Sixteen matched healthy volunteers served as control subjects. T2 lesion volumes were assessed with a semiautomatic technique. VBM and TBSS were used for the GM and WM analyses, respectively, to compare regional GM volumes and fractional anisotropy (FA) values in the two groups. Results TBSS analysis revealed a pattern of diffuse FA reductions in patients with CIS at the cluster level (P < .05). Regions of decreased FA involved most of the WM pathways, including the corticospinal tracts, corpus callosum, and superior and inferior longitudinal fasciculi. There were no significant differences between the two groups in terms of global GM, WM, or cerebrospinal fluid volume or in terms of regional GM volume. Conclusion Diffuse WM damage not accompanied by any change in GM or WM volume is observed in patients with CIS. This suggests that WM involvement plays a relevant role in the early phases of MS. Subsequently detected GM damage may be secondary to WM alterations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Radiological Society of North America (RSNA)
ISSN:	0033-8419
Last Modified:	09 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/139493

Citation Data

Cited 66 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item