Mild cognitive impairment: same identity for different entities

Serra, Laura, Giulietti, Giovanni, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Spanò, Barbara, Torso, Mario, Castelli, Diana, Perri, Roberta, Fadda, Lucia, Marra, Camillo, Caltagirone, Carlo and Bozzali, Marco 2013. Mild cognitive impairment: same identity for different entities. Journal of Alzheimer's Disease 33 (4) , pp. 1157-1165. 10.3233/jad-2012-121663

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Abstract

This study investigates whether different patterns of grey matter (GM) loss may account for the different neuropsychological profiles observed in patients with amnestic (a-) and non-amnestic (na-) mild cognitive impairment (MCI), and may predict patients' clinical evolution. Fifty-five consecutive individuals complaining of cognitive dysfunction (referred to specialist dementia clinics) were screened and included in the study if they met the diagnostic criteria for MCI on a neurodegenerative basis. After an extensive neuropsychological assessment, patients were classified as suffering from a-MCI or na-MCI. Twenty-eight healthy individuals were also recruited and served as controls. All participants underwent magnetic resonance imaging at 3T, including conventional images and volumetric scans. Volumetric data were processed using voxel-based morphometry to assess between-group differences in regional GM volumes and correlations with neuropsychological performances. When compared to controls, a-MCI patients showed prominent GM volume reductions in the medial temporal lobes, while those with na-MCI showed reduced GM volumes in the orbito-frontal cortex and basal ganglia. In a-MCI patients, significant associations were found between verbal long-term memory performance and GM volumes in the hippocampus. Conversely, in na-MCI patients, associations were found between scores at tests exploring executive functions and GM volumes in the orbito-frontal cortex. At one-year follow-up, conversions were recorded exclusively toward Alzheimer's disease (AD) in the a-MCI group, and toward non-AD dementia in the na-MCI group. This study confirms that MCI is a heterogeneous clinical identity including different neurodegenerative entities; specific patterns of regional GM loss appear to account for specific neuropsychological features and are likely to predict patients' clinical evolution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	IOS Press
ISSN:	1387-2877
Date of Acceptance:	9 October 2012
Last Modified:	09 Nov 2022 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/139520

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