Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study.

Serra, Laura, Musicco, Massimo, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Torso, Mario, Spanò, Barbara, Mastropasqua, Chiara, Giulietti, Giovanni, Marra, Camillo, Bruno, Giuseppe, Koch, Giacomo, Caltagirone, Carlo and Bozzali, Marco 2015. Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study. Neurobiology of Aging 36 (2) , pp. 592-600. 10.1016/j.neurobiolaging.2014.10.010

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Abstract

This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0197-4580
Date of Acceptance:	10 October 2014
Last Modified:	09 Nov 2022 10:27
URI:	https://orca.cardiff.ac.uk/id/eprint/139524

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